Danielle, 21... student at the University of Connecticut.

“Be soft. Do not let the world make you hard. Do not let pain make you hate. Do not let the bitterness steal your sweetness. Take pride that even though the rest of the world may disagree, you still believe it to be a beautiful place.”

Kurt Vonnegut (via strangestcities)
Apr 21st at 8AM / via: strangestcities / op: strangestcities / reblog / 37 notes

s0rrysunshine:

MASSIVE GIVEAWAY!:)

So this is my first big giveaway from this blog, since I deleted my old one. And there’s tons of things to win!!:)
Rules:
-You must be following my blog (s0rrysunshine.tumblr.com)
-You must reblog. Likes don’t count.
Reblog as many times as you want, the more you do the higher chance you have of winning!

Winner Gets:

  • Autographed book “It” by Alexa Chung
  • Alex Turner’s guitar pic from the Arctic Monkeys MSG show 2014
  • Polaroid 300 camera
  • Live at the Apollo Arctic Monkeys DVD+CD (only the dvd is pictured but you’ll get both)
  • Is This It - The Strokes
  • The 2nd Law - Muse
  • Contra - Vampire Weekend
  • Deja Entendu - Brand New
  • AM - Arctic Monkeys
  • Nevermind - Nirvana
  • Wolfgang Amadeus Phoenix - Phoenix
  • Whatever People Say I Am, That’s What I’m Not - Arctic Monkeys
  • Modern Vampires of the City - Vampire Weekend
  • Suck It and See - Arctic Monkeys
  • Plans - Death Cab For Cutie
  • Humbug - Arctic Monkeys
  • Vampire Weekend - Vampire Weekend
  • Coexist - The XX
  • Favourite Worst Nightmare
  • Donnie Darko DVD
  • 500 Days of Summer DVD
  • Harry Potter Box Set (DVD’S)
  • Scott Pilgrim VS The World DVD
  • My Neighbor Totoro DVD

reblog as much as you want, you MUST be following (i’ll check) &the winner will be picked May 10th. I’ll ship worldwide, and i’ll message the winner and post it on my blog when they’re picked. Good luck!

Apr 21st at 8AM / via: greatdanes-cheekbones / op: s0rrysunshine / reblog / 58,178 notes

“Say what you will about the sweet miracle of unquestioning faith, I consider a capacity for it terrifying and absolutely vile!
Kurt Vonnegut”

(via whyilikekurtvonnegut)

(Source: sexanddrugsandcats)

Apr 18th at 4PM / via: bossypants / op: sexanddrugsandcats / reblog / 206,028 notes

justlearningasigo:

JESUS DUMBLEDORE FUCKING CHRIST

I love this soo much.

(Source: stupidfuckingquestions)

Apr 18th at 7AM / via: montezumasblues / op: stupidfuckingquestions / reblog / 382,037 notes
  • Uhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh
Uhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh

buzzfeed:

mississippiabigail:

how i communicate

Ah, yes, the song of my people.

(Source: apcockulus)

Apr 18th at 7AM / via: bossypants / op: apcockulus / reblog / 46,858 notes

(Source: obsessedwiththeroyals)

Apr 17th at 3AM / via: pleatedjeans / op: obsessedwiththeroyals / reblog / 335,699 notes
neurolove:

GABA!
The next neurotransmitter I will talk about is GABA (gamma-aminobutyric acid). GABA is the primary inhibitory neurotransmitter in the brain, but depending on the receptor type, it can be inhibitory or excitatory. We mainly talk about it’s actions as an inhibitory neurotransmitter, but it’s important to note that it can act as an excitatory one as well, depending on the receptor that it acts upon.
There are two main receptor subtypes for GABA, which are known as GABA-A and GABA-B receptors.  GABA-A receptors are ligand-gated chloride channels.  Hopefully, without further explanation, from my past entries, this makes sense.  If you need a refresher, this means that when GABA interacts with these GABA-A receptors, they undergo a conformational change that opens their “pore” to allow chloride (Cl-) ions to flow through.  Since Cl- is negative, it can hyperpolarize the cell (make it more negative) and make it less likely to fire, in the simplest explanation. 
GABA-B receptors are more complex, as they are those G-protein coupled receptors.  Downstream effects can be to open Cl- channels or K+ channels (since there is more potassium inside the cell, K+ might flow out or even if it does not move, shunt an excitatory signal if it arrives while the channels are open), amongst other things.
Inhibitory actions can be very complex on their own and really help to fine-tune the rest of the brain’s activity.  The image above shows a presynaptic cell below and a postsynaptic neuron above it, as GABA is involved in the hypothalamus/feeding behavior- found in this paper (Richards & Berthoud, 2006).


Ahhh My research :) Miss you GABA.. but I know you’re always with me. 

View in High Quality →

neurolove:

GABA!

The next neurotransmitter I will talk about is GABA (gamma-aminobutyric acid). GABA is the primary inhibitory neurotransmitter in the brain, but depending on the receptor type, it can be inhibitory or excitatory. We mainly talk about it’s actions as an inhibitory neurotransmitter, but it’s important to note that it can act as an excitatory one as well, depending on the receptor that it acts upon.

There are two main receptor subtypes for GABA, which are known as GABA-A and GABA-B receptors.  GABA-A receptors are ligand-gated chloride channels.  Hopefully, without further explanation, from my past entries, this makes sense.  If you need a refresher, this means that when GABA interacts with these GABA-A receptors, they undergo a conformational change that opens their “pore” to allow chloride (Cl-) ions to flow through.  Since Cl- is negative, it can hyperpolarize the cell (make it more negative) and make it less likely to fire, in the simplest explanation. 

GABA-B receptors are more complex, as they are those G-protein coupled receptors.  Downstream effects can be to open Cl- channels or K+ channels (since there is more potassium inside the cell, K+ might flow out or even if it does not move, shunt an excitatory signal if it arrives while the channels are open), amongst other things.

Inhibitory actions can be very complex on their own and really help to fine-tune the rest of the brain’s activity.  The image above shows a presynaptic cell below and a postsynaptic neuron above it, as GABA is involved in the hypothalamus/feeding behavior- found in this paper (Richards & Berthoud, 2006).

Ahhh My research :) Miss you GABA.. but I know you’re always with me. 

Apr 14th at 4PM / via: neurolove / op: neurolove / reblog / 195 notes